The Centre of Innovation for Complementary Health Product (COI-CHP) was established in 2016 as a strategic partnership with Enterprise Singapore (formerly known as SPRING Singapore) to support Singapore-based Complementary Health Product (CHP) enterprises meet the growing challenges and technological advances.
With a multi-disciplinary and research-intensive team, this national Centre offers innovative and customised solutions to enterprises in CHP product development that includes product formulation, chemical and biological analysis, as well as safety and efficacy testing. The three categories of CHP are traditional medicines, health supplements and functional foods.
Chemical & Biological Analysis
- Active ingredients testing
- Antioxidant testing
- Banned substances testing
- Heavy metal and mineral testing
- In vivo pharmacokinetic testing
- Metabolomics study
- Microbial testing
- Residual antibiotic testing
- Residual pesticide testing
Safety & Efficacy
- Anti-viral activity testing
- Gut microbiome study
- In vitro & in vivo efficacy testing
- In vitro & in vivo toxicological analysis
- In vitro & in vivo prebiotic effect analysis
- Skin irritation testing
- Stability studies
- Innovative functional food formulation
- Innovative herbal product formulation
- Applied nutrition research
- Li Huan, Lim Esther, Ang Gladys, Lim Zhi Qing, Cai Hui Martin, Loh Jo-anne, Ng Celine, Seetoh Peijia, Tian Feng Edmund, Goh Lay Beng. Qualitative and quantitative analysis of Arnebiae Radix and Dictamni Cortex and efficacy study of herbal extracts on allergic contact dermatitis using 3D human reconstructed epidermis. Chinese Herbal Medicines, 2021, https://doi.org/10.1016/j.chmed.2021.10.006.
- Narayanasamy Sarawathi, Chan Kit Lun, Cai Hui Martin, Ahmad Hilman Bin Abdul Razak, Tay Boon Keat, Miao Huang. Biobutanol production from sugarcane bagasse by Clostridium beijerinckii strains. Biotechnology and Applied Biochemistry, 2019, https://doi.org/10.1002/bab.1865.
- Yang Hong, Xue Xue Jia, Li Huan, Siti Norasikin Apandi, Tay-Chan Su Chin, Ong Seng Poon. Tian Edmund. The relative antioxidant activity and steric structure of green tea catechins–A kinetic approach. Food Chemistry, 2018, 257, 399-405.
- Chong Lor Huai, Li Huan, Isaac Wetzel, Cho Han Sang, Toh Yi Chin. A liver-immune coculture array for predicting systemic drug-induced skin sensitization. Lab on a Chip, 2018, 18, 3239-3250.
- Lee Kok Onn, Tian Feng Edmund, Cai Hui Martin, Wang Hong, Chan Yiong Huak, Sim Meng Kwoon. Bioavailability of Orally Administered Des-Aspartate-Angiotensin I in Human Subjects. Drugs R&D, 2018, 18, 51-54.
- Yang Hong, Xue Xue Jia, Li Huan, Tay-Chan Su Chin, Ong Seng Poon. Tian Feng, Edmund. A new parameter to simultaneously assess antioxidant activity for multiple phenolic compounds present in food products. Food Chemistry, 2017, 229, 215-222.
- Tian Feng Edmund, Li Huan, Cai Hui Martin, Kong Matthew. A Pressing Need: Standardisation of TCM Granule Products. Research & Reviews: Journal of Botanical Sciences, 2017, 6, 75-77.
- Li Huan, Yang Hong, Xue XueJia, Liu Xiao, Tian Feng, Poh Yan Hong, Cai Hao, Lee Yian Hoon, Yu Hanry, Ong Seng Poon, Cai Bao Chang. A Metabolomics Approach to Study the Dual Modulation by Characterization of Chemical Alteration during Processing of Gardeniae Fructus using UPLC-ESI-QTOF. Analytical Methods, 2016, 8, 3629-3635.
Specialist Diploma in Laboratory Management and Instrumentation
Enrol in this course to be exposed to the fundamental separation science behind various advanced techniques such as chromatography and mass spectrometry. Gain awareness on the importance of ISO systems in the context of laboratory management and client servicing.
For Course Details, pleae click here.
Dr Edmund, TIAN Feng
- BSc (Zhejiang University, China, Biomedical Engineering)
- PhD (University of Otago, New Zealand, Analytical Chemistry)
Dr Tian has more than 15 years of experience in analytical science, both in R&D and industrial consultancy services for the TCM & Functional food industry, including studies on the quality, safety and efficacy of herbal products. Dr Tian has initiated and operationalised more than 20 industrial TCM studies, with a total project value of S$300K.
Dr LI Huan
- BSc (Harbin University of Commerce, China, Pharmaceutical Engineering)
- BSc (1st Class Honours, University of Aston, UK, Biomedical Science)
- MSc (Nanjing University of Chinese Medicine, China, Pharmacy in Chinese Medicine)
- PhD (Nanjing University of Chinese Medicine, China, Pharmacy in Chinese Medicine)
Dr Li has 10 years of experience in pharmacokinetics study, instrumental analysis, basic animal surgery, 3D cell culture, virus and bacteria work. Prior to joining TP, she had worked on 3D hepatocyte and drug toxicity testing for 2 years at the Institute of Bioengineering and Nanotechnology, A*STAR.
Dr XUE Xuejia
- BSc (Nanjing University, China, Chemistry & Polymer)
- MEng (Southeast University, China, Chemistry & Chemical Engineering)
- PhD (National University of Singapore, Chemistry)
Dr Xue has more than 10 years of teaching and research experience in the area of physical and inorganic chemistry, analytical chemistry, as well as instrumental analysis. Dr Xue main areas of research include the analysis of chemical and biological materials, as well as the instrumental-based chemical testing of HPLC, LC-QqQ and QTOF. Recently, he has developed the chromatographic methods for profiling active ingredients in herbs, supplements, and functional foods.
Dr YANG Hong
- BSc (West China Medical School of Sichuan University, Pharmacy)
- MSc (West China Medical School of Sichuan University, Pharmacy)
- PhD (National University of Singapore, Medicinal Chemistry)
Dr Yang has more than 10 years of experience with instrumental analysis of small organic molecules using HPLC, GC and MS technologies. Prior to joining Temasek Polytechnic, Dr Yang was an Analytical Scientist in a biotechnology company with expertise in analytical methods development on LC-MS. Her current research areas of interest are in drug discovery from natural products and analytical methods development for complex biological/chemical system.