Diploma in Medical Biotechnology (T64)

The Diplomas in Biotechnology and Biomedical Science have been merged to form the Diploma in Medical Biotechnology from AY2019. This course is Singapore's first medical biotechnology diploma approved by MOE .

2019 Planned Intake: 110 JAE 2019 Last Aggregate Score: 10

Cell therapy, personalized medicine, regenerative medicine, drug discovery, clinical diagnostics, genetic engineering – do these terms excite you?  Do you want to be involved in the research and development that leads to new biological discoveries for improving healthcare and our everyday life?   Or do you want to play a part in assisting medical doctors’ diagnoses through performing a range of laboratory tests to help identify diseases?  If your answer is yes, this course is for you. 

The future of medicine relies on biotechnology.  Demand for more sensitive and earlier detection tests will continue to fuel the biotechnology industry.  This course provides detailed knowledge of key concepts in cell technology, molecular analysis, microbiology technology, biochemical analysis, clinical diagnostics, and how these approaches are applied in areas relevant to medical applications such as restoring functions of tissues or organs that are injured or diseased, using stem cells to treat diseases, developing customised treatment to individual patient, performing tests to assist medical doctors’ diagnosis, etc. 

Not only does this course equip you with broad theoretical knowledge and critical understanding of principles in biotechnology and clinical diagnostics, but it also helps you to gain the practical skills required to underpin a career within a research or clinical environment.  You will also be exposed to new emerging technologies, such as stem cell therapy, point-of-care diagnostic testing, and personalised medicine research that would transform medicine and revolutionise the healthcare system.

After developing a solid foundation in biotechnology and clinical diagnostics in the first three semesters, you will choose one of the two diploma options in the 4th semester.  Personalized Medicine Research option mainly trains you to be research and production technologists in research institutes and biotechnology companies.  Medical Laboratory Technology option mainly trains you to be clinical technologists working in hospital clinical laboratories. 

The elective subjects that you will take in the third year will allow you greater specialisation in your selected field, especially in the areas of translational medical research or clinical laboratory practice.  To further hone your technical skills, you will undergo a six-month attachment either locally or overseas in the clinical laboratories, or biotechnology and biomedical industries.


What you will learn

  • Discover, Develop, and Invent

    Do you want to be a scientist in the future to discover or invent something that is useful to human health?  You will have the chance to explore and modify medical compounds, and be involved in the invention of new diagnostics and treatments.

  • Helping to Diagnose Diseases

    Passionate about helping to heal the sick? You will acquire the scientific skills to help doctors save lives! You will learn major techniques and skills to help diagnose diseases in a clinical laboratory.

  • Applying Biotechnology in Our Daily Life

    Through modern technologies, such as stem cell therapy, genetic engineering and enzyme technology, biotechnology is not only shaping diverse aspects of medicine, but also improving our everyday life. You will learn applications of biotechnology in solving real-life problems. You will also have the chance to work on personalized medicine research, which has revolutionised modern medicine.

Notable Features

  • The first medical biotechnology diploma in Singapore
  • The only polytechnic biotechnology diploma course to offer Personalized Medicine Research option
  • A Maker’s Lab to provide opportunities for students to propose and try their own ideas with guidance from experienced supervisors
  • Collaborative training programme with major hospitals and expert lectures by physicians working at the forefront of healthcare
  • Besides training students for the current jobs in biotechnology and biomedical science areas, this course also prepares students for the future, emerging areas.

Academic Architecture

The Academic Architecture of the School of Applied Science emphasises the following:

  • Building a strong foundation core among first year students
  • Strengthening key concepts and skills in the diploma-specialised content among second year students
  • Enhancing applied learning for final year students

The Academic Architecture also aims to develop collaborative and self-directed learning skills for our students to be life-long learners through more real-life and applied learning experiences.  One notable outcome of this is the smooth transition of student interns into companies as employees.   

Elective Cluster Subjects

Students will be required to read an Elective Cluster offered by the School. The Elective Clusters to be offered by this course, and the subjects under these clusters, are summarised below:



Medical Biotechnology (T64)

Clinical Laboratory Practice

  • Haematology  
  • Blood Banking

Translational Medical Research 

  • Translational Medical Science

Career Prospects

Biotechnology and Biomedical Industry

  • R&D Technologist
  • Laboratory Technologist
  • Scientific Officer
  • QA/QC Technologist
  • Sales & Marketing Executive

Healthcare Industry

  • Medical Technologist
  • Clinical Research Technologist

Further Education

Graduates from the School of Applied Science (ASC) are able to gain entry into various degree courses offered by United Kingdom, Australia and local universities. Most of the top overseas universities offer advanced standing to our Diploma graduates. This could typically mean one to two years’ exemption from their bachelor degree programmes, depending on their overall grades for their three years of the diploma course and the field of chosen studies at the university.

Our graduates may also apply for admission to NUS, NTU and SIT. Please refer to their respective websites for more information. For NUS Level 1 subjects, diploma graduates may apply for subject placement tests. Exemptions from Level 1 subjects would be granted only if students pass the relevant subject placement tests.

For other degree courses and advanced standing, please click this link to access diploma to degree courses for guidance.

Entry Requirements

To be eligible for consideration for admission, applicants must obtain 26 points or better for the net ELR2B2 aggregate score (i.e. English Language, 2 relevant subjects and best 2 other subjects, including CCA Bonus Points) and meet the minimum entry requirements of this course. CCA cannot be used to meet the minimum entry requirements.

Minimum Entry Requirements

English Language (EL1)* Grades 1-7
Mathematics (E or A) Grades 1-6
One of the following Science subjects: Grades 1-6

  • Biology
  • Biotechnology
  • Chemistry
  • Combined Science
  • Food & Nutrition
  • Physics/Engineering Science
  • Science (Chemistry, Biology)
  • Science (Physics, Biology)
  • Science (Physics, Chemistry)/Physical Science
Any two other subjects, excluding CCA  

* Sijil Pelajaran Malaysia (SPM)/ Unified Examination Chinese (UEC) holders must have a minimum of grade 6 for the relevant English Language subject (e.g. Bahasa Inggeris).

Note: Applicants with partial or complete colour appreciation deficiency are not eligible to apply.

Course Structure

TP Fundamentals (TPFun) Subjects

Subject code Subject LevelCredit Units

In this subject, you will learn how to conduct research for relevant information and validate information sources. You will also learn to recognise and avoid plagiarism, and follow standard citation and referencing guidelines when presenting information. In the course of learning, you will be required to plan, prepare and present information appropriately in written and oral form.


In this subject, you will be taught how to conduct effective meetings while applying team communication strategies and the skills for documenting meeting notes. You will be required to write clear emails, using the appropriate format, language, tone and style for an audience. You will also be taught to communicate appropriately in and for an organisation when using various platforms.


In this subject, you will be taught how to use persuasive language in written documents. You will be required to use information to your advantage to verbally communicate and convince an audience about your idea, product or service. Skills such as persuasive vocabulary, language features, graphical illustrations, tone and style would also be covered.


This subject presents you with a panoramic view of current local and global issues, which may have long term implications for Singapore. You will learn to apply critical thinking tools to examine current issues, support your views with relevant research and up-to-date data, articulate an informed opinion and mature as civicminded individuals.


This subject is designed for learners from all disciplines to embrace innovation in either their specialised field or beyond.  You will first be introduced to the Design Thinking framework and learn how to develop problem statements and ideate solutions.  Next, you will discover the tools for prototyping and innovation, such as 3D printing and laser cutting at TP’s Makerspace+ facility.     


LEAP 1, 2 and 3 are three fundamental subjects that seek to cultivate in you, the attitude, skills and knowledge for the development of your leadership competencies.  This character-based leadership programme enables you to develop your life-skills through establishing personal core values, which will become the foundation for your leadership credibility and influence.


LEAP 1, 2 and 3 are three fundamental subjects that seek to cultivate in you, the attitude, skills and knowledge for the development of your leadership competencies.  This character-based leadership programme enables you to develop your life-skills through establishing personal core values, which will become the foundation for your leadership credibility and influence.


LEAP 1, 2 and 3 are three fundamental subjects that seek to cultivate in you, the attitude, skills and knowledge for the development of your leadership competencies.  This character-based leadership programme enables you to develop your life-skills through establishing personal core values, which will become the foundation for your leadership credibility and influence.


This subject will help you develop both the physical and technical skills in your chosen sports or fitness activities. Through a structured curriculum that facilitates group participation, practice sessions and mini competitions, you will learn to build lifelong skills such as resilience, leadership, communication and teamwork. Physical activity sessions will be supplemented by health-related topics to provide you with a holistic approach to healthy living.


This Career Readiness programme comprises three core subjects – Personal Management, Career Preparation and Career Management. It seeks to help you understand your career interests, values, personality and skills for career success. It also equips you with the necessary skills for seeking and securing jobs, and to develop professional work ethics.


This Career Readiness programme comprises three core subjects – Personal Management, Career Preparation and Career Management. It seeks to help you understand your career interests, values, personality and skills for career success. It also equips you with the necessary skills for seeking and securing jobs, and to develop professional work ethics.


This Career Readiness programme comprises three core subjects – Personal Management, Career Preparation and Career Management.  It seeks to help you understand your career interests, values, personality and skills for career success.  It also equips you with the necessary skills for seeking and securing jobs, and to develop professional work ethics.


This subject provides essential skills and knowledge to prepare you for an overseas experience. You will examine the elements of culture and learn the key principles of cross-cultural communication. In addition, you will gain an appreciation and awareness of the political, economic, technological and social landscape to function effectively in a global environment.


You will examine your own identity, study different forms of diversity and apply strategies to inspire positive collaboration in a diverse workplace. Through a residential stay, you will have the opportunity to experience living and working with peers from different backgrounds.


This subject highlights the inter-connectedness of the world today, bringing about what it means to be a Global Citizen. You will gain an awareness of the impacts of globalisation and the concepts of social responsibility and sustainable community development. This subject also challenges you to be actively engaged in a social or environmental project.


Whether telling stories, building monuments or celebrating rites of passage, expressions of culture are at the core of cultural diversity. In this subject, everyday objects, artistic creations and popular culture are explored as ways of understanding the values and beliefs of a society. By taking this subject, you will benefit by acquiring a greater understanding and appreciation of the complexities surrounding our cultural assets.


This is a subject where you will be free to pursue an area of interest through a self-directed approach, guided by staff. You will be expected to demonstrate a sense of curiosity for learning, initiate an opportunity to acquire knowledge and skills, and reflect on your learning journey throughout the subject.


This programme involves attachment at industries related to your course of study. You are expected to undertake various activities discussed with and assigned by the participating host organisations. The programme enables you to apply knowledge and skills acquired in the course of your study to solve practical problems in the real workplace. Emphasis is also placed on training of transferable skills such as teamwork, interpersonal, written and oral communication skills.


Diploma Subjects - Core Subjects

Subject code Subject LevelCredit Units

This subject covers the basic theory and practical knowledge of inorganic and physical chemistry. Topics include fundamentals of chemistry, atomic structure and chemical bonding, stoichiometry and equilibria concepts of a chemical reaction.


This subject investigates the important fundamentals of microbiology and its relevance to the food, biomedical and biotechnology industries. It covers the types of microorganisms, their cultivation and growth as well as their control.


This subject covers the biology of cells of higher organisms, including structure-function relationships of cellular membranes and internal organelles, cell cycle and nuclear division, transport mechanisms and cell communication, cell motility and the cytoskeleton and cell death. Basic laboratory skills involving the study of cell structures with the use of cell staining techniques and microscopy will also be introduced in this subject.


This subject introduces the fundamentals of organic chemistry and the essential biomolecules present in biological systems. The structures and properties of biomolecules, as well as the basic concepts of bioenergetics will also be introduced to illustrate how these interactions lead to metabolism.


The subject covers the fundamentals of deoxyribonucleic acid (DNA), flow of genetic information, ribonucleic acid (RNA), as well as how processes like replication, transcription and translation operate in prokaryotes and eukaryotes. Basic practical knowledge and molecular laboratory techniques will be introduced.


This subject provides you with a basic understanding of human anatomy and physiology. Topics include anatomy of human organs and organ systems and their functions.


This subject provides basic theoretical and practical knowledge of mammalian cell culture.  It covers the requirements for establishing and maintaining cell cultures both in the laboratory and in large-scale operations. It also discusses the important applications of the cell culture technique in the biological and medical sciences.


This subject covers the basics of biostatistics and application of statistics in clinical practices by converting clinical and laboratory experiences into quantitative statements. The topics covered include using statistical tools to summarize data, test for differences between test groups, analyse rates and proportions, establish or validate confidence intervals, and testing for trends. It also covers the application of biostatistics in different clinical cases. The topics covered include t-test, ANOVA and non-parametric tests.


This subject covers molecular techniques in analysing DNA, RNA and proteins, as well as diagnostic platforms and instrumentation, which includes assay development, assay criteria and assay validation.  It also addresses the regulatory requirements for diagnostic assays and the pathways to commercialization.


This subject focuses on the applications of immunological, analytical and separation techniques in the field of medical biotechnology.  Basic concepts and techniques for extraction, purification and analysis of biomolecules will be covered. An introduction to good manufacturing practice (GMP) is included.


This subject will cover the practices of good documentation and laboratory management, laboratory reagent preparation and research skills. This subject will provide opportunities for conceptualization of medical biotechnology related project, experimental design and project implementation.


This subject provides a framework for you to solve practical problems, conduct research work and/ or develop studies, through a self-managed project. The scope of the subject includes project proposal, investigative studies, analysis, interpretation of results, written report and presentation.


Diploma Option Subjects

Personalized Medicine Research Option

Subject code Subject LevelCredit Units

This subject covers an overview of the concepts of tissue engineering, stem cells, biomaterials and a review on extracellular matrix, followed by topics on cell-cell and cell-matrix interactions at both the theoretical and experimental levels.


This subject provides the fundamentals of DNA assembly and regulation of gene expression, as well as basic engineering principles to design biological systems and biofactories. It covers the laboratory techniques on genome editing, sequence analysis, as well as the potential applications of synthetic biology in medical biotechnology.


This subject provides an overview of genomes, transcriptomes, proteomes, metabolomes and other omics information to profiling of health and disease. Genome sequencing techniques, as well as bioinformatics and computational analysis will be introduced.


Medical Laboratory Technology Option

Subject code Subject LevelCredit Units

This subject focuses on the pathophysiological changes in disease and the application of clinical chemistry concepts for the diagnosis, prognosis, monitoring and screening of diseases.


This subject introduces the basic knowledge of general and systemic pathology, as well as structural and functional abnormalities of organs and organ systems. Basic principles and skills related to histopathological diagnosis will also be covered.


This subject covers the host-microbe interactions with emphasis on infectious diseases in humans. It includes various modes of transmission, diagnosis, prevention and control of infectious diseases caused by bacteria, viruses, fungi and parasites.


Diploma Subjects - Elective Cluster Subjects

Clinical Laboratory Practice

Subject code Subject LevelCredit Units

This subject covers the theoretical, practical and clinical aspects of blood transfusion. Emphasis is given on the application of immunologic principles as applied to blood grouping, antibody screening, identification and compatibility testing. It also stresses the importance of laboratory quality control and clinical considerations in transfusion practices.


This subject covers theoretical foundations and practical skills in haematology. It includes development of blood cells, diseases and disorders related to blood as well as bone marrow. It focuses on screening, diagnosis, prognosis and monitoring of haematological diseases and disorders.


Translational Medical Science (TRANS)

Subject code Subject LevelCredit Units

This subject equips students with knowledge and skills in conducting translational medical research projects.  It covers designing, planning, experimenting, and touble shooting skills for translational medical research projects.  It also introduces various data analysis and reporting skills.    


Free Elective Subjects

Subject code Subject LevelCredit Units

This subject equips you with the fundamental knowledge of pharmaceutical downstream manufacturing processes. Topics covered include industrial aspects of drug production, manufacturing techniques and packaging technologies. It also covers solid, liquid and gaseous dosage formulation design and characterisation. The importance of cGMP and the associated regulatory aspects are also covered.


This subject covers the fundamental knowledge and applications of Current Good Manufacturing Practice (cGMP) in the pharmaceutical and biopharmaceutical industries. Topics include an overview of cGMP, documentation and record keeping, contamination control, in-process control, validation, and introduction to process improvement techniques.


Graduation Requirements

Cumulative Grade Point Average min 1.0
TP Fundamentals Subjects 40 credit units
Diploma Subjects
- Core Subjects
- Elective Subjects

71 credit units
min 9 credit units
Total Credit Units Completed min 120 credit units


Contact Us

For general enquiries, please contact:

School of Applied Science

  (65) 6788 2000
  (65) 6782 5498